Ausgewählte Publikationen mit Beteiligung der AZKIM-Partner*innen

 

2022

Devi S, Zimmermann-Klemd AM, Fiebich BL, Heinrich M, Gründemann C, Steinberger P, Kowarschik S, Huber R (2022). Immunosuppressive activity of non-psychoactive Cannabis sativa L. extract on the function of human T lymphocytes. Int Immunopharmacol. 103:108448. PubMed

 

2021

Lederer AK, Baginski A, Raab L, Joos S, Valentini J, Klocke C, Samstag Y, Hübner K, Andreeva I, Simmet T, Syrovets T, Hafner S, Freisinger A, Storz MA, Huber R (2021). Complementary medicine in Germany: a multi-centre cross-sectional survey on the usage by and the needs of patients hospitalized in university medical centers. BMC Complement Med Ther. 21(1):285. PubMed

Elgaafary M, Lehner J, Fouda AM, Hamed A, Ulrich J, Simmet T, Syrovets T, El-Agrody AM (2021). Synthesis and evaluation of antitumor activity of 9-methoxy-1H-benzo[f]chromene derivatives. Bioorg Chem 116:105402. PubMed

Elgaafary M, Fouda AM, Mohamed HM, Hamed A, El-Mawgoud HKA, Jin L, Ulrich J, Simmet T, Syrovets T, El-Agrody AM (2021). Synthesis of beta-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms. Front Chem 9:759148. PubMed

Stolz R, Klafke N, Kröger B, Boltenhagen U, Kaltenbach A, Heine R, Idler C, Layer M, Kohler S, Winkler M, Voiss P, Joos S, Mahler C (2021). Creating evidence for naturopathic nursing interventions in oncology - a systematic approach. Z Evid Fortbild Qual Gesundhwes. 166:1-7. PubMed

Lederer AK, Chikhladze S, Kohnert E, Huber R, Müller A (2021). Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery-A Narrative Review. Diagnostics (Basel), 11(11):2099. PubMed

Samstag Y, Bogert NV, Wabnitz GH, Din S, Therre M, Leuschner F, Katus HA, Konstandin MH (2021). Reactive Oxidative Species-Modulated Ca2+ Release Regulates β2 Integrin Activation on CD4+ CD28null T Cells of Acute Coronary Syndrome Patients. J Immunol. 205(8):2276-2286. PubMed

Valentini J, Klocke C, Güthlin C, Joos S (2021). Integration of Complementary and Integrative Medicine Competencies in General Practice Postgraduate Education – Development of a Novel Competency Catalogue in Germany. BMC Complement Med Ther. 21(1):250. PubMed

Waterstradt A, Winker M, Zimmermann-Klemd AM, Devi S, Lederer AK, Huber R, Gründemann C (2021). Silicon Resorption from Equisetum arvense Tea - A Randomized, Three-Armed Pilot Study. Planta Med. online ahead of print. PubMed

Müller A, Zimmermann-Klemd AM, Lederer AK, Hannibal L, Kowarschik S, Huber R, Storz MA (2021). A Vegan Diet Is Associated with a Significant Reduction in Dietary Acid Load: Post Hoc Analysis of a Randomized Controlled Trial in Healthy Individuals. Int. J. Environ. Res. Public Health 18(19), 9998. PubMed

Jin L, Han X, Zhang X, Zhao Z, Ulrich J, Syrovets T, Simmet T Identification of Oleanolic Acid as Allosteric Agonist of Integrin alphaM by Combination of In Silico Modeling and In Vitro Analysis. Front Pharmacol. 12:702529. PubMed

Schwill S, Krug K, Valentini J, Rentschler A, Nikendei C, Szecsenyi J, Bugaj TJ (2021). How to strengthen basic competencies in self-care–a pre-post interventional study with postgraduate trainees in Family Medicine in Germany. Postgrad Med. 133(5), 572. PubMed

Harasim A, Krone M , Tony H-P, Gawlik M, Witte T, Joos S, Gernert M, Schmalzing M, Morbach H, Schwaneck E (2021). Use of Complementary and Alternative Medicine in Patients with Primary Immunodeficiency: a Multicentric Analysis of 101 Patients. J Clin Immunol. 41(3):585-594. PubMed

Kohnert E, Kreutz C, Binder N, Hannibal L, Gorkiewicz G, Müller A, Storz MA, Huber R, Lederer AK (2021). Changes in Gut Microbiota after a Four-Week Intervention with Vegan vs. Meat-Rich Diets in Healthy Participants: A Randomized Controlled Trial. Microorganisms 9(4):727. PubMed

Schmiech M, Ulrich J, Lang SJ, Buchele B, Paetz C, St-Gelais A, Syrovets T, Simmet T (2021). 11-Keto-alpha-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells. Molecules 26(2):366. PubMed

Balta E, Kramer J, Samstag Y (2021). Redox Regulation of the Actin Cytoskeleton in Cell Migration and Adhesion: On the Way to a Spatiotemporal View. Front Cell Dev Biol 8:618261. PubMed

 

 

2020

Lederer AK, Maul-Pavicic A, Hannibal L, Hettich M, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Sehnert B, Salzer U, Klein R, Voll RE, Samstag Y, Huber R (2020). Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial. Clin Nutr. 39(11):3241-3250. PubMed

Zimmermann-Klemd AM, Reinhardt JK, Nilsu T, Morath A, Falanga CM, Schamel WW, Huber R, Hamburger M, Gründemann C (2020). Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function. Filoterapia 146:104694. PubMed

Kilper A, Müller A, Huber R, Reimers N, Schütz L, Lederer A-K (2020). Complementary medicine in orthopaedic and trauma surgery: a cross-sectional survey on usage and needs. BMJ Open 10(9):e037192. PubMed

Wild B, Brenner J, Joos S, Samstag Y, Buckert M, Valentini J (2020). Acupuncture in persons with an increased stress level - Results from a randomized-controlled pilot trial. PLoS One 15(7):e0236004. PubMed

Manz EJ, Sertel S, Szecsenyi J, Plinkert PK, Joos S (2020). Acupuncture as Complementary Treatment for Acute Tinnitus: A Randomized Controlled Pilot Study. Complement Med Res. 28(2): 96-103. PubMed

Engler J, Güthlin C, Bertram L, Joos S, Valentini J (2020). Wie nutzen Hausärzte E-Learning? Ergebnisse einer explorativen Prozessevaluation eines webbasierten Trainings für Hausärzte zur Kommunikation über Komplementärmedizin mit Krebspatienten. Deutscher Ärzteverlag, Z Allg Med 96 (12): 502-507. doi

Stolz R, Kröger B, Joos S, Mahler C (2020). Die Zerstäubung von ätherischen Ölen in der Raumluft zur Prävention und/oder Behandlung von Infektionen der Atemwege. Corona-Special der Pflegewissenschaft: Interdisziplinäre Aspekte der Corona-Pandemie und deren Implikationen für Pflege und Gesellschaft. Journal für Pflegewissenschaft und Pflegepraxis, ISSN 1662-3029, 2020;49-52

Liang J, Ziegler JD, Jahraus B, Orlik C, Blatnik R, Blank N, Niesler B, Wabnitz G, Ruppert T, Hübner K, Balta E, Samstag Y (2020). Piperlongumine Acts as an Immunosuppresssant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation. Front Immunol. 11:1172. PubMed

Lang SJ, Schmiech M, Hafner S, Paetz C, Werner K, El Gaafary M, Schmidt CQ, Syrovets T, Simmet T (2020). Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 21(11):4090. PubMed

Du Preez CI, Gründemann C, Reinhardt JK, Mumbengegwi DR, Huber R (2020). Immunmodulatory effects of some Namibian plants traditionally used for treating inflammatory diseases. J Ethnopharmacol. 254:112683. PubMed

Nasr S, Rady M, Sebak A, Gomaa I, Fayad W, Gaafary ME, Abdel-Kader M, Syrovets T, Simmet T (2020). A Naturally Derived Carrier for Photodynamic Treatment of Squamous Cell Carcinoma: In Vitro and In Vivo Models. Pharmaceutics. 12(6):494. PubMed

Kauerova T, Gonec T, Jampilek J, Hafner S, Gaiser AK, Syrovets T, Fedr R, Soucek K, Kollar P (2020). Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis. Int J Mol Sci. 21(10):3416. PubMed

Khouya T, Ramchoun M, Amrani S, Harnafi H, Rouis M, Couchie D, Simmet T, Alem C (2020). Anti-inflammatory and anticoagulant effects of polyphenol-rich extracts from Thymus atlanticus: An in vitro and in vivo study. J Ethnopharmacol 252:112475. PubMed

Hamed A, Frese M, Elgaafary M, Syrovets T, Sewald N, Simmet T, Shaaban M (2020). Synthesis of novel feruloyl dipeptides with proapoptotic potential against different cancer cell lines. Bioorg Chem 97: 103678. PubMed

Güthlin C, Bartsch H, Joos S, Längler A, Lampert C, Ritter C, Schildmann J, Weis J, Wilhelm M, Witt C, Horneber M (2020). KOKON: A Germany-Wide Collaborative Research Project to Identify Needs, Provide Information, Foster Communication and Support Decision-Making about Complementary and Alternative Medicine in Oncology. Complement Med Res. 27:105-111. PubMed

Zimmermann-Klemd AM, Reinhardt JK, Morath A, Schamel WW, Steinberger P, Leitner J, Huber R, Hamburger M, Gründemann C (2020). Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds. Front Pharmacol. 11:402. PubMed

Jin L, Schmiech M, El Gaafary M, Zhang X, Syrovets T, Simmet T (2020). A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages. Phytomedicine. 68:153181. PubMed

Chilczuk T, Steinborn C, Breinlinger S, Zimmermann-Klemd AM, Huber R, Enke H, Enke D, Niedermeyer THJ, Gründemann C (2020). Hapalindoles from the Cyanobacterium Hapalosihon sp. Inhibit T Cell Proliferation. Planta Med. 86(2):96-103. PubMed

Kuderer S, Helmert E, Szöke H, Joos S, Kohl M, Svaldi J, Beissner F, Andrasik F, Vagedes J (2020). Increasing Warmth in Adolescents with Anorexia Nervosa: A Randomized Controlled Crossover Trial Examining the Efficacy of Mustard and Ginger Footbaths. Evid Based Complement Alternat Med. 2020:2416582. PubMed

Klafke N, Mahler C, von Hagens C, Uhlmann L, Bentner M, Schneeweiß A, Mueller A, Szecsenyi J, Joos S (2020). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: results from a randomized controlled trial. Cancer Med. 8(8):3666-3676. PubMed

 

2019

Lederer A-K, Hannibal L, Hettich M, Behringer S, Spiekerkoetter U, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Simmet T, Schmiech M, Maul-Pavicic A, Samstag Y, Huber R (2019). Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants. Nutrients. 11(11):2815. PubMed

Schmiech M, Lang SJ, Syrovets T, Simmet T (2019). Data on cytotoxic activity of an Artemisia annua herbal preparation and validation of the quantification method for active ingredient analysis. Data Brief. 27:104635. PubMed

Schmiech M, Lang SJ, Ulrich J, Werner K, Rashan LJ, Syrovets T, Simmet T (2019). Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells. Nutrients. 11(10):2341. PubMed

El Gaafary M, Hafner S, Lang SJ, Jin L, Sabry OM, Vogel CV, Vanderwal CD, Syrovets T, Simmet T (2019). A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells. Mar Drugs. 17(8):437. PubMed

Schmiech M, Lang SJ, Werner K, Rashan LJ, Syrovets T, Simmet T (2019). Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Boswellia Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells. Molecules. 24(11):2153. PubMed

Lang SJ, Schmiech M, Hafner S, Paetz C, Steinborn C, Huber R, Gaafary ME, Werner K, Schmidt CQ, Syrovets T, Simmet T (2019). Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomedicine. 62:152962. PubMed

Baars EW, Belt-van Zoen E, Breitkreuz T, Martin D, Matthes H, von Schoen-Angerer T, Soldner G, Vagedes J, van Wietmarschen H, Patijn O, Willcox M, von Flotow P, Teut M, von Ammon K, Thangavelu M, Wolf U, Hummelsberger J, Nicolai T, Hartemann P, Szöke H, McIntyre M, van der Werf ET, Huber R (2019). The Contribution of Complementary and Alternative Medicine to Reduce Antibiotic Use: A Narrative Review of Health Concepts, Prevention, and Treatment Strategies. Evid Based Complement Alternat Med. 2019:5365608. PubMed

Liang J, Hänsch GM, Hübner K, Samstag Y (2019). Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. Adv Biol Regul. 71:79–87. PubMed

Mahler C, Klafke N, Bentner M, Blaser G, Joos S (2019). Naturheilkundliche Pflegemaßnahmen in der Onkologie. Pflegezeitschrift 72(3):56-59. Link.

 

2018

Lederer A-K, Schmucker C, Kousoulas L, Fichtner-Feigl S, Huber R (2018). Naturopathic Treatment and Complementary Medicine in Surgical Practice. Dtsch Arztebl Int. 115(49):815–21. PubMed

Liang J, Jahraus B, Balta E, Ziegler JE, Hübner K, Blank N, Niesler B, Wabnitz GH, Samstag Y (2018). Sulforaphane Inhibits Inflammatory Responses of Primary Human T-cells by increasing ROS and depleting Glutathione. Front Immunol. 9:2584. PubMed

Gründemann C, Huber R (2018). Chemoprevention with isothiocyanates - From bench to bedside. Cancer Lett. 414:26-33. PubMed

Valentini J, Flum E, Schwill S, Krug K, Szecsenyi J, Joos S (2018). Komplementäre und Integrative Medizin in der Facharztweiterbildung Allgemeinmedizin – Ergebnisse einer Bedarfserhebung bei Ärzten in Weiterbildung. Complement Med Res. 25(4):233-239. PubMed

Valentini J, Glassen K, Eicher C, Washington-Dorando P, Weinschenk S, Musselmann B, Steinhaeuser J, Joos S (2018). Kritische Diskussion sollte mehr gefördert werden - eine qualitative Auswertung der Lehrevaluation von Medizinstudierenden zur komplementärmedizinischen Lehre. Dtsch Med Wochenschr. 143(14):e125-e130. PubMed

Wabnitz GH, Kirchgessner H, Jahraus B, Umansky L, Shenolikar S, Samstag Y (2018). Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. Mol Cell Biol. 38(22):e00041-18. PubMed

Seeland I, Xiong Y, Orlik C, Deibel D, Prokosch S, Küblbeck G, Jahraus B, De Stefano D, Moos S, Kurschus FC, Arnold B, Samstag Y (2018). The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development. PLoS Biol. 16(7):e2005380. Pubmed

 

2017

El Gaafary M, Ezzat SM, El Sayed AM, Sabry OM, Hafner S, Lang S, Schmiech M, Syrovets T, Simmet T (2017). Acovenoside A induces mitotic catastrophe followed by apoptosis in non-small-cell lung cancer cells. J Nat Prod. 80:3203-10. PubMed

Huber R, Schlodder D, Effertz C, Rieger S, Tröger W (2017). Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer. BMC Complement Altern Med. 17(1):465. PubMed

Lederer AK, Pisarski P, Kousoulas L, Fichtner-Feigl S, Hess C, Huber R (2017). Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review. BMC Surg. 17(1):125. PubMed

Stock-Schröer B, Huber R, Joos S, Klose K (2017). Evaluation of the current status of Rehabilitation, Physical Medicine and Naturopathy education 10 years after the reform of the Medical Licensure Act – a nationwide survey of German Medical Universities. GMS J Med Educ. 34(1):Doc3, ISSN 2366-5017. PubMed

 

2016

Ezzat SM, El Gaafary M, El Sayed AM, Sabry OM, Ali ZY, Hafner S, Schmiech M, Jin L, Syrovets T, Simmet T (2016). The cardenolide glycoside Acovenoside A affords protective activity in doxorubicin-induced cardiotoxicity in mice. J Pharmacol Exp Ther. 358:262-70. PubMed

Hoffmann A, Klein SD, Gründemann C, Garcia-Käufer M, Wolf U, Huber R (2016). Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study. Phytother Res. 30(9):1481. PubMed

Klafke N, Mahler C, von Hagens C, Blaser G, Bentner M, Joos S (2016). Developing and implementing a complex Complementary and Alternative (CAM) nursing intervention for breast and gynecologic cancer patients undergoing chemotherapy-report from the CONGO (complementary nursing in gynecologic oncology) study. Support Care Cancer. 24(5):2341-2350. PubMed

Krug K, Kraus K, Herrmann K, Joos S (2016). Complementary and alternative medicine (CAM) as part of primary health care in Germany - comparison of patients consulting general practitioners and CAM practitioners: a cross-sectional study. BMC Complement Altern Med. 16(1):409. PubMed

Roser E, Gründemann C, Engels I, Huber R (2016). Antibacterial in vitro effects of preparations from Anthroposophical Medicine. BMC Complement Altern Med. 16(1):372. PubMed