Ausgewählte Publikationen mit Beteiligung der AZKIM-Partner



Schwill S, Krug K, Valentini J, Rentschler A, Nikendei C, Szecsenyi J, Bugaj TJ (2021). How to strengthen basic competencies in self-care–a pre-post interventional study with postgraduate trainees in Family Medicine in Germany. Postgraduate Medicine (accepted)

Harasim A, Krone M , Tony H-P, Gawlik M, Witte T, Joos S, Gernert M, Schmalzing M, Morbach H, Schwaneck E (2021). Use of Complementary and Alternative Medicine in Patients with Primary Immunodeficiency: a Multicentric Analysis of 101 Patients. J Clin Immunol. 41(3):585-594. PubMed

Schmiech S, Ulrich J, Lang SJ, Buchele B, Paetz C, St-Gelais A, Syrovets T, Simmet T (2021). 11-Keto-alpha-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells. Molecules 26(2):366. doi



Engler J, Güthlin C, Bertram L, Joos S, Valentini J (2020). Wie nutzen Hausärzte E-Learning? Ergebnisse einer explorativen Prozessevaluation eines webbasierten Trainings für Hausärzte zur Kommunikation über Komplementärmedizin mit Krebspatienten. Deutscher Ärzteverlag, Z Allg Med; 96 (12): 502-50. doi

Lederer A-K, Maul-Pavicic A, Hannibal L, Hettich M, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Sehnert B, Salzer U, Klein R, Voll RE, Samstag Y, Huber R (2020). Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial. Clin Nutr. 39(11):3241-3250. PubMed

Zimmermann-Klemd AM, Reinhardt JK, Nilsu T, Morath A, Falanga CM, Schamel WW, Huber R, Hamburger M, Gründemann C (2020). Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function. Filoterapia. 146:104694. PubMed

Kilper A, Müller A, Huber R, Reimers N, Schütz L, Lederer A-K (2020). Complementary medicine in orthopaedic and trauma surgery: a cross-sectional survey on usage and needs. BMJ Open.10(9):e037192. PubMed

Wild B, Brenner J, Joos S, Samstag Y, Buckert M, Valentini J (2020). Acupuncture in persons with an increased stress level - Results from a randomized-controlled pilot trial. PLoS One. 15(7):e0236004. PubMed

Manz EJ, Sertel S, Szecsenyi J, Plinkert PK, Joos S (2020). Acupuncture as Complementary Treatment for Acute Tinnitus: A Randomized Controlled Pilot Study. Complement Med Res. Jul 24;1-8. Online ahead of print. PubMed

Stolz R, Kröger B, Joos S, Mahler C (2020). Die Zerstäubung von ätherischen Ölen in der Raumluft zur Prävention und/oder Behandlung von Infektionen der Atemwege. Corona-Special der Pflegewissenschaft: Interdisziplinäre Aspekte der Corona-Pandemie und deren Implikationen für Pflege und Gesellschaft. Journal für Pflegewissenschaft und Pflegepraxis, ISSN 1662-3029, 2020;49-52

Liang J, Ziegler JD, Jahraus B, Orlik C, Blatnik R, Blank N, Niesler B, Wabnitz G, Ruppert T, Hübner K, Balta E, Samstag Y (2020). Piperlongumine Acts as an Immunosuppresssant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation. Front Immunol. 11:1172. PubMed

Lang SJ, Schmiech M, Hafner S, Paetz C, Werner K, El Gaafary M, Schmidt CQ, Syrovets T, Simmet T (2020). Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 21(11):4090. PubMed

Du Preez CI, Gründemann C, Reinhardt JK, Mumbengegwi DR, Huber R (2020). Immunmodulatory effects of some Namibian plants traditionally used for treating inflammatory diseases. J Ethnopharmacol. 254:112683. PubMed

Hamed A, Frese M, Elgaafary M, Syrovets T, Sewald N, Simmet T, Shaaban M (2020). Synthesis of novel feruloyl dipeptides with proapoptotic potential against different cancer cell lines. Bioorg Chem 97: 103678. PubMed

Güthlin C, Bartsch H, Joos S, Längler A, Lampert C, Ritter C, Schildmann J, Weis J, Wilhelm M, Witt C, Horneber M (2020). KOKON: A Germany-Wide Collaborative Research Project to Identify Needs, Provide Information, Foster Communication and Support Decision-Making about Complementary and Alternative Medicine in Oncology. Complement Med Res. 27:105-111. PubMed

Zimmermann-Klemd AM, Reinhardt JK, Morath A, Schamel WW, Steinberger P, Leitner J, Huber R, Hamburger M, Gründemann C (2020). Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds. Front Pharmacol. 11:402. PubMed

Jin L, Schmiech M, El Gaafary M, Zhang X, Syrovets T, Simmet T (2020). A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages. Phytomedicine. 68:153181. PubMed

Chilczuk T, Steinborn C, Breinlinger S, Zimmermann-Klemd AM, Huber R, Enke H, Enke D, Niedermeyer THJ, Gründemann C (2020). Hapalindoles from the Cyanobacterium Hapalosihon sp. Inhibit T Cell Proliferation. Planta Med. 86(2):96-103. PubMed

Kuderer S, Helmert E, Szöke H, Joos S, Kohl M, Svaldi J, Beissner F, Andrasik F, Vagedes J (2020). Increasing Warmth in Adolescents with Anorexia Nervosa: A Randomized Controlled Crossover Trial Examining the Efficacy of Mustard and Ginger Footbaths. Evid Based Complement Alternat Med. 2020:2416582. PubMed 



Lederer A-K, Hannibal L, Hettich M, Behringer S, Spiekerkoetter U, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Simmet T, Schmiech M, Maul-Pavicic A, Samstag Y, Huber R (2019). Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants. Nutrients. 11(11):2815. PubMed

Schmiech M, Lang SJ, Syrovets T, Simmet T (2019). Data on cytotoxic activity of an Artemisia annua herbal preparation and validation of the quantification method for active ingredient analysis. Data Brief. 27:104635. PubMed

Schmiech M, Lang SJ, Ulrich J, Werner K, Rashan LJ, Syrovets T, Simmet T (2019). Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells. Nutrients. 11(10):2341. PubMed

Klafke N, Mahler C, von Hagens C, Uhlmann L, Bentner M, Schneeweiß A, Mueller A, Szecsenyi J, Joos S (2020). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: results from a randomized controlled trial. Cancer Med. 8(8):3666-3676. PubMed

El Gaafary M, Hafner S, Lang SJ, Jin L, Sabry OM, Vogel CV, Vanderwal CD, Syrovets T, Simmet T (2019). A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells. Mar Drugs. 17(8):437. PubMed

Schmiech M, Lang SJ, Werner K, Rashan LJ, Syrovets T, Simmet T (2019). Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Boswellia Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells. Molecules. 24(11):2153. PubMed

Lang SJ, Schmiech M, Hafner S, Paetz C, Steinborn C, Huber R, Gaafary ME, Werner K, Schmidt CQ, Syrovets T, Simmet T (2019). Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomedicine. 62:152962. PubMed

Liang J, Hänsch GM, Hübner K, Samstag Y (2019). Sulforaphane as anticancer agent: A double-edged sword? Tricky balance between effects on tumor cells and immune cells. Adv Biol Regul. 71:79–87. PubMed

Mahler C, Klafke N, Bentner M, Blaser G, Joos S (2019). Naturheilkundliche Pflegemaßnahmen in der Onkologie. Pflegezeitschrift 72(3):56-59. Link.



Lederer A-K, Schmucker C, Kousoulas L, Fichtner-Feigl S, Huber R (2018). Naturopathic Treatment and Complementary Medicine in Surgical Practice. Dtsch Arztebl Int. 115(49):815–21. PubMed

Liang J, Jahraus B, Balta E, Ziegler JE, Hübner K, Blank N, Niesler B, Wabnitz GH, Samstag Y (2018). Sulforaphane Inhibits Inflammatory Responses of Primary Human T-cells by increasing ROS and depleting Glutathione. Front Immunol. 9:2584. PubMed

Gründemann C, Huber R (2018). Chemoprevention with isothiocyanates - From bench to bedside. Cancer Lett. 414:26-33. PubMed

Valentini J, Flum E, Schwill S, Krug K, Szecsenyi J, Joos S (2018). Komplementäre und Integrative Medizin in der Facharztweiterbildung Allgemeinmedizin – Ergebnisse einer Bedarfserhebung bei Ärzten in Weiterbildung. Complement Med Res. 25(4):233-239. PubMed

Valentini J, Glassen K, Eicher C, Washington-Dorando P, Weinschenk S, Musselmann B, Steinhaeuser J, Joos S (2018). Kritische Diskussion sollte mehr gefördert werden - eine qualitative Auswertung der Lehrevaluation von Medizinstudierenden zur komplementärmedizinischen Lehre. Dtsch Med Wochenschr. 143(14):e125-e130. PubMed



Lederer AK, Pisarski P, Kousoulas L, Fichtner-Feigl S, Hess C, Huber R (2017). Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review. BMC Surg. 17(1):125. PubMed

Huber R, Schlodder D, Effertz C, Rieger S, Tröger W (2017). Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer. BMC Complement Altern Med. 17(1):465. PubMed

Stock-Schröer B, Huber R, Joos S, Klose K (2017). Evaluation of the current status of Rehabilitation, Physical Medicine and Naturopathy education 10 years after the reform of the Medical Licensure Act – a nationwide survey of German Medical Universities. GMS J Med Educ. 34(1):Doc3, ISSN 2366-5017. PubMed

El Gaafary M, Ezzat SM, El Sayed AM, Sabry OM, Hafner S, Lang S, Schmiech M, Syrovets T, Simmet T (2017). Acovenoside A induces mitotic catastrophe followed by apoptosis in non-small-cell lung cancer cells. J Nat Prod. 80:3203-10. PubMed



Hoffmann A, Klein SD, Gründemann C, Garcia-Käufer M, Wolf U, Huber R (2016). Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study. Phytother Res. 30(9):1481. PubMed

Roser E, Gründemann C, Engels I, Huber R (2016). Antibacterial in vitro effects of preparations from Anthroposophical Medicine. BMC Complement Altern Med. 16(1):372. PubMed

Ezzat SM, El Gaafary M, El Sayed AM, Sabry OM, Ali ZY, Hafner S, Schmiech M, Jin L, Syrovets T, Simmet T (2016). The cardenolide glycoside Acovenoside A affords protective activity in doxorubicin-induced cardiotoxicity in mice. J Pharmacol Exp Ther. 358:262-70. PubMed

Klafke N, Mahler C, von Hagens C, Blaser G, Bentner M, Joos S (2016). Developing and implementing a complex Complementary and Alternative (CAM) nursing intervention for breast and gynecologic cancer patients undergoing chemotherapy-report from the CONGO (complementary nursing in gynecologic oncology) study. Support Care Cancer. 24(5):2341-2350. PubMed

Krug K, Kraus K, Herrmann K, Joos S (2016). Complementary and alternative medicine (CAM) as part of primary health care in Germany - comparison of patients consulting general practitioners and CAM practitioners: a cross-sectional study. BMC Complement Altern Med. 16(1):409. PubMed